Excerpt from: Elizabeth Drew, "Terrifying Trump," New York Review of Books; see also, plus (1).
image from article
Trump’s possible mental deficiencies are also a troubling question: serious medical professionals suspect he has narcissistic personality disorder [JB - see], and also oncoming dementia [JB - see] , judging from his limited vocabulary. (If one compares his earlier appearances on YouTube, for example a 1988 interview with Larry King [JB - see], it appears that Trump used to speak more fluently and coherently than he does now, especially in some of his recent rambling presentations.) His perseverating about such matters as the size of his inauguration crowd, or the fantasy that three to five million illegal voters denied him a popular vote victory (he got these estimates from a dodgy source who has yet to offer documentation), or, as he told CIA employees, the number of times he’s been on the cover of Time (sometimes inflating the actual number) has become a joke, but it also suggests that there may be something troubling about his mental state. Numerous eminent psychologists and psychiatrists have written about or expressed their concerns about Trump’s mental stability.2(2) They did this despite the fact that the American Psychiatric Association has a rule that a diagnosis shouldn’t be proffered unless the person under discussion has been clinically examined.
Image from, with caption: Dr. Harold Bornstein wrote “I am pleased to report that Mr. Trump has had no significant medical problems."
Another Bornstein image from
From Wikipedia, the free encyclopedia
This article is about the group of cholesterol-lowering drugs. For the amino acid, see Statine. For inhibiting hormones, see Releasing and inhibiting hormones.
|Biological target||HMG-CoA reductase|
Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications. Statins have been found to reduce cardiovascular disease (CVD) and mortality in those who are at high risk. The evidence is strong that statins are effective for treating CVD in the early stages of a disease (secondary prevention) and in those at elevated risk but without CVD (primary prevention).
Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormalities in liver enzyme tests. Additionally, they have rare but severe adverse effects, particularly muscle damage. They inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol. High cholesterol levels have been associated with cardiovascular disease (CVD).
As of 2010, a number of statins are on the market: atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. In 2005, sales were estimated at US$18.7 billion in the United States. The best-selling statin is atorvastatin, which in 2003 became the best-selling pharmaceutical in history. The manufacturer Pfizer reported sales of US$12.4 billion in 2008. Due to patent expirations, several statins are now[when?] available as less expensive generics.
Clinical practice guidelines generally recommend people to try "lifestyle modification", including a cholesterol-lowering diet and physical exercise, before statin use. Statins or other pharmacologic agents may be recommended for those who do not meet their lipid-lowering goals through diet and lifestyle changes. Statins appear to work equally well in males and females.
In 2016 the United States Preventative Services Task Force recommended statins for those who have at least one risk factor for heart disease, are between 40 and 75 years old, and have at least a 10% risk of heart disease. The risk factors for heart disease included dyslipidemia, diabetes, high blood pressure, and smoking. The risk of heart disease is estimated using the ACC/AHA Pooled Cohort equation. They recommended selective use of low-to-moderate doses statins in the same adults who have a calculated 10-year CVD event risk of 7.5–10% or greater.
Most evidence suggests that statins are effective in preventing heart disease in those with high cholesterol, but no history of heart disease. A 2013 Cochrane review found a decrease in risk of death and other poor outcomes without any evidence of harm. For every 138 people treated for 5 years one fewer dies and for every 49 treated one fewer has an episode of heart disease. A 2011 review reached similar conclusions. And a 2012 review found benefits in both women and men. A 2010 review concluded that treating people with no history of cardiovascular disease reduces cardiovascular events in men but not women, and provides no mortality benefit in either sex. Two other meta analyses published that year, one of which used data obtained exclusively from women, found no mortality benefit in primary prevention.
The National Institute for Health and Clinical Excellence (NICE) recommends statin treatment for adults with an estimated 10 year risk of developing cardiovascular disease that is greater than 10%. Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL or those with diabetes, age 40–75 with LDL-C 70–190 mg/dl; or in those with a 10-year risk of developing heart attack or stroke of 7.5% or more. In this latter group, statin assignment was not automatic, but was recommended to occur only after a clinician-patient risk discussion with shared decision making where other risk factors and lifestyle are addressed, the potential for benefit from a statin is weighed against the potential for adverse effects or drug interactions and informed patient preference is elicited. Moreover, if a risk decision was uncertain, factors such as family history, coronary calcium score, ankle-brachial index, and an inflammation test (hs-CRP ≥ 2.0 mg/L) were suggested to inform the risk decision. Additional factors that could be used were an LDL-C ≥ 160 or a very high lifetime risk. However, critics such as Steven E. Nissen say that the AHA/ACC guidelines were not properly validated, overestimate the risk by at least 50%, and recommend statins for patients who will not benefit, based on populations whose observed risk is lower than predicted by the guidelines. The European Society of Cardiology and the European Atherosclerosis Society recommend the use of statins for primary prevention, depending on baseline estimated cardiovascular score and LDL thresholds.
Statins are effective in decreasing mortality in people with pre-existing CVD. They are also advocated for use in patients at high risk of developing heart disease. On average, statins can lower LDL cholesterol by 1.8 mmol/l (70 mg/dl), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. They have less effect than the fibrates or niacin in reducing triglycerides and raising HDL-cholesterol ("good cholesterol").
Statins have been studied for improving operative outcomes in cardiac and vascular surgery. Mortality and adverse cardiovascular events were reduced in statin groups.
While no direct comparison exists, all statins appear effective regardless of potency or degree of cholesterol reduction. There do appear to be some differences between them, with simvastatin and pravastatin appearing superior in terms of side-effects.
A comparison of atorvastatin, pravastatin and simvastatin, based on their effectiveness against placebos, found, at commonly prescribed doses, no differences among the statins in reducing cardiovascular morbidity and mortality, and lipids.
In children statins are effective at reducing cholesterol levels in those with familial hypercholesterolemia.[needs update] Their long term safety is, however, unclear. Some recommend that if lifestyle changes are not enough statins should be started at 8 years old.
Statins may be less effective in reducing LDL cholesterol in people with familial hypercholesterolemia, especially those with homozygous deficiencies. These people have defects usually in either the LDL receptor or apolipoprotein B genes, both of which are responsible for LDL clearance from the blood. Statins are still first line treatments in familial hypercholesterolemia,although other cholesterol-reducing measures may be required. In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications.
Contrast induced nephropathy
A 2014 meta-analysis found that statins could reduce the risk of contrast-induced nephropathy by 53% in people undergoing coronary angiography/percutaneous interventions. The effect was found to be stronger among those with preexisting kidney dysfunction or diabetes mellitus.
|Choosing a statin for people with special considerations|
|Condition||Commonly recommended statins||explanation|
|Kidney transplantation recipients taking ciclosporin||Pravastatin or Fluvastatin||Drug interactions are possible, but studies have not shown that these statins increase exposure to ciclosporin.|
|HIV-positive people taking protease inhibitors||Atorvastatin, Pravastatin or Fluvastatin||Negative interactions are more likely with other choices|
|Persons taking gemfibrozil, a non-statin cholesterol-lowering drug||Atorvastatin||Combining gemfibrozil and a statin increases risk of rhabdomyolysis and subsequently kidney failure|
|Persons taking the anticoagulant warfarin||Any statin||The statin use may require that the warfarin dose be changed, as some statins increase the effect of warfarin.|
The most important adverse side effects are muscle problems, an increased risk of diabetes, and increased liver enzymes in the blood due to liver damage. Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. This could be because as statins inhibit the enzyme (HMG-CoA reductase) that makes cholesterol, statins also inhibit the other processes of this enzyme, such as CoQ10production, and CoQ10production is important for muscle cells and in blood sugar regulation.
Other possible adverse effects include cognitive loss, neuropathy, pancreatic and hepatic dysfunction, and sexual dysfunction. The rate at which such events occur has been widely debated, in part because the risk/benefit ratio of statins in low risk populations is highly dependent on the rate of adverse events. A Cochrane group meta analysis of statin clinical trials in primary prevention found no evidence of excess adverse events among those treated with statins compared to placebo. Another meta analysis found a 39% increase in adverse events in statin treated people relative to those receiving placebo, but no increase in serious adverse events. The author of one study argued that adverse events are more common in clinical practice than in randomized clinical trials. A systematic review concluded that while clinical trial meta analyses underestimate the rate of muscle pain associated with statin use, the rates of rhabdomyolysis are still "reassuringly low" and similar to those seen in clinical trials (about 1–2 per 10,000 person years). A systematic review co-authored by Ben Goldacre concluded that only a small fraction of side effects reported by people on statins are actually attributable to the statin.
There are anecdotal reports of cognitive decline with statins. In 2012, in recognition of an increase in anecdotal reports and increasing concerns over the relationship between statins and memory loss (including reports of transient global amnesia), forgetfulness and confusion, the Food and Drug Administration(FDA) added to its required labeling on statin drugs a warning about possible cognitive impacts. The effects are described as rare, non-serious, and reversible upon cessation of treatment.
One 2013 systematic review concluded that the available evidence was "not strongly supportive of a major adverse effect of statins". Another meta-analysis from the same year concluded that there is moderate quality evidence of no increase in dementia, mild cognitive impairment or cognitive performance scores, although the strength of the evidence was limited, particularly for high doses.
In observational studies 10–15% of people who take statins experience muscle problems; in most cases these consist of muscle pain. These rates, which are much higher than those seen in randomized clinical trials have been the topic of extensive debate and discussion.
Rare reactions include myopathies such as myositis (inflammation of the muscles) or even rhabdomyolysis (destruction of muscle cells), which can in turn result in life-threatening kidney injury. The risk of statin-induced rhabdomyolysis increases with older age, use of interacting medications such as fibrates, and hypothyroidism. Coenzyme Q10 (ubiquinone) levels are decreased in statin use; CoQ10 supplements are sometimes used to treat statin-associated myopathy, though evidence of their efficacy is lacking as of 2007. The gene SLCO1B1 (Solute carrier organic anion transporter family member 1B1) codes for an organic anion-transporting polypeptide that is involved in the regulation of the absorption of statins. A common variation in this gene was found in 2008 to significantly increase the risk of myopathy.
Records exist of over 250,000 people treated from 1998 to 2001 with the statin drugs atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. The incidence of rhabdomyolyis was 0.44 per 10,000 patients treated with statins other than cerivastatin. However, the risk was over 10-fold greater if cerivastatin was used, or if the standard statins (atorvastatin, fluvastatin, lovastatin, pravastatin, or simvastatin) were combined with fibrate (fenofibrate or gemfibrozil) treatment. Cerivastatin was withdrawn by its manufacturer in 2001.
All commonly used statins show somewhat similar results, but the newer statins, characterized by longer pharmacological half-lives and more cellular specificity, have had a better ratio of efficacy to lower adverse effect rates. Some researchers have suggested hydrophilic statins, such as fluvastatin, rosuvastatin, and pravastatin, are less toxic than lipophilic statins, such as atorvastatin, lovastatin, and simvastatin, but other studies have not found a connection; the risk of myopathy was suggested to be lowest with pravastatin and fluvastatin, probably because they are more hydrophilic and as a result have less muscle penetration. Lovastatin induces the expression of gene atrogin-1, which is believed to be responsible in promoting muscle fiber damage. Tendon rupture does not appear to occur.
Statins are associated with a slightly increased risk of diabetes (2–17% in one review). Higher doses have a greater effect, but the decrease in cardiovascular disease outweighs the risk of developing diabetes.
Several meta-analyses have found no increased risk of cancer, and some meta-analyses have found a reduced risk.
Statins may reduce the risk of esophageal cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, and possibly prostate cancer. They appear to have no effect on the risk of lung cancer, kidney cancer, breast cancer,pancreatic cancer, or bladder cancer.
Combining any statin with a fibrate or niacin (other categories of lipid-lowering drugs) increases the risks for rhabdomyolysis to almost 6.0 per 10,000 person-years. Monitoring liver enzymes and creatine kinase is especially prudent in those on high-dose statins or in those on statin/fibrate combinations, and mandatory in the case of muscle cramps or of deterioration in kidney function.
Consumption of grapefruit or grapefruit juice inhibits the metabolism of certain statins. Bitter oranges may have a similar effect.Furanocoumarins in grapefruit juice (i.e. bergamottin and dihydroxybergamottin) inhibit the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of most statins (however, it is a major inhibitor of only lovastatin, simvastatin, and to a lesser degree, atorvastatin) and some other medications (flavonoids (i.e. naringin) were thought to be responsible). This increases the levels of the statin, increasing the risk of dose-related adverse effects (including myopathy/rhabdomyolysis). The absolute prohibition of grapefruit juice consumption for users of some statins is controversial.
The FDA notified healthcare professionals of updates to the prescribing information concerning interactions between protease inhibitors and certain statin drugs. Protease inhibitors and statins taken together may increase the blood levels of statins and increase the risk for muscle injury (myopathy). The most serious form of myopathy, rhabdomyolysis, can damage the kidneys and lead to kidney failure, which can be fatal.
Mechanism of action
Main article: Cholesterol homeostasis
Statins act by competitively inhibiting HMG-CoA reductase, the first committed enzyme of the mevalonate pathway. Because statins are similar in structure to HMG-CoA on a molecular level, they will fit into the enzyme's active site and compete with the native substrate (HMG-CoA). This competition reduces the rate by which HMG-CoA reductase is able to produce mevalonate, the next molecule in the cascade that eventually produces cholesterol. A variety of natural statins are produced by Penicillium and Aspergillus fungi as secondary metabolites. These natural statins probably function to inhibit HMG-CoA reductase enzymes in bacteria and fungi that compete with the producer.
Inhibiting cholesterol synthesis
By inhibiting HMG-CoA reductase, statins block the pathway for synthesizing cholesterol in the liver. This is significant because most circulating cholesterol comes from internal manufacture rather than the diet. When the liver can no longer produce cholesterol, levels of cholesterol in the blood will fall. Cholesterol synthesis appears to occur mostly at night, so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, but have shown no difference in the long-acting atorvastatin.
Increasing LDL uptake
In rabbits, liver cells sense the reduced levels of liver cholesterol and seek to compensate by synthesizing LDL receptors to draw cholesterol out of the circulation. This is accomplished via proteases that cleave membrane-bound sterol regulatory element binding proteins, which then migrate to the nucleus and bind to the sterol response elements. The sterol response elements then facilitate increased transcription of various other proteins, most notably, LDL receptor. The LDL receptor is transported to the liver cell membrane and binds to passing LDL and VLDL particles (colloquially, "bad cholesterol"), mediating their uptake into the liver, where the cholesterol is reprocessed into bile salts and other byproducts. The bile salts are secreted into the duodenum during digestion of fats and are subsequently reabsorbed later in the jejunum and ileum.
Decreasing of specific protein prenylation
Statins, by inhibiting the HMG CoA reductase pathway, simultaneously inhibit the production of both cholesterol and specific prenylated proteins (see diagram).This inhibitory effect on protein prenylation may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL have not shown the same cardiovascular risk benefits in studies as statins, and may also account for certain of the benefits seen in cancer reduction with statins. In addition, the inhibitory effect on protein prenylation may also be involved in a number of unwanted side effects associated with statins, including muscle pain (myopathy) and elevated blood sugar (diabetes).
As noted above, statins exhibit action beyond lipid-lowering activity in the prevention of atherosclerosis. The ASTEROID trial showed direct ultrasound evidence of atheroma regression during statin therapy. Researchers hypothesize that statins prevent cardiovascular disease via four proposed mechanisms (all subjects of a large body of biomedical research):
- Improve endothelial function
- Modulate inflammatory responses
- Maintain plaque stability
- Prevent thrombus formation
In 2008, the JUPITER study showed benefit in those who had no history of high cholesterol or heart disease, but only elevated C-reactive protein levels. The conclusions of this study are, however, controversial.
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
The statins are divided into two groups: fermentation-derived and synthetic. They include, along with brand names, which may vary between countries:
|Cerivastatin||Lipobay, Baycol (withdrawn from the market in August, 2001 due to risk of serious rhabdomyolysis)||Synthetic||various CYP3A isoforms|
|Fluvastatin||Lescol, Lescol XL||Synthetic||CYP2C9|
|Lovastatin||Mevacor, Altocor, Altoprev||Naturally occurring, fermentation-derived compound. It is found in oyster mushrooms and red yeast rice||CYP3A4|
|Mevastatin||Compactin||Naturally occurring compound found in red yeast rice||CYP3A4|
|Pitavastatin||Livalo, Livazo, Pitava||Synthetic||CYP2C9 and CYP2C8 (minimally)|
|Pravastatin||Pravachol, Selektine, Lipostat||Fermentation-derived (a fermentation product of bacterium Nocardia autotrophica)||Non-CYP|
|Rosuvastatin||Crestor||Synthetic||CYP2C9 and CYP2C19|
|Simvastatin||Zocor, Lipex||Fermentation-derived (simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus)||CYP3A4|
|Simvastatin + ezetimibe||Vytorin, Inegy||Combination therapy: statin + cholesterol absorption inhibitor|
|Lovastatin + niacin extended-release||Advicor, Mevacor||Combination therapy|
|Atorvastatin + amlodipine||Caduet, Envacar||Combination therapy: statin + calcium antagonist|
|Simvastatin + niacin extended-release||Simcor||Combination therapy|
LDL-lowering potency varies between agents. Cerivastatin is the most potent, (withdrawn from the market in August, 2001 due to risk of serious rhabdomyolysis) followed by (in order of decreasing potency), rosuvastatin, atorvastatin, simvastatin, lovastatin, pravastatin, and fluvastatin. The relative potency of pitavastatin has not yet been fully established.
Some types of statins are naturally occurring, and can be found in such foods as oyster mushrooms and red yeast rice. Randomized controlled trials have found these foodstuffs to reduce circulating cholesterol, but the quality of the trials has been judged to be low. Due to patent expiration, most of the block-buster branded statins have been generic since 2012, including atorvastatin, the largest-selling branded drug.
|Statin equivalent dosages|
|% LDL reduction (approx.)||Atorvastatin||Fluvastatin||Lovastatin||Pravastatin||Rosuvastatin||Simvastatin|
|10–20%||–||20 mg||10 mg||10 mg||–||5 mg|
|20–30%||–||40 mg||20 mg||20 mg||–||10 mg|
|30–40%||10 mg||80 mg||40 mg||40 mg||5 mg||20 mg|
|40–45%||20 mg||–||80 mg||80 mg||5–10 mg||40 mg|
|46–50%||40 mg||–||–||–||10–20 mg||80 mg*|
|50–55%||80 mg||–||–||–||20 mg||–|
|* 80-mg dose no longer recommended due to increased risk of rhabdomyolysis|
|Starting dose||10–20 mg||20 mg||10–20 mg||40 mg||10 mg; 5 mg if hypothyroid, >65 yo, Asian||20 mg|
|If higher LDL reduction goal||40 mg if >45%||40 mg if >25%||20 mg if >20%||--||20 mg if LDL >190 mg/dL (4.87 mmol/L)||40 mg if >45%|
|Optimal timing||Anytime||Evening||With evening meals||Anytime||Anytime||Evening|
Main article: Statin development
In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, began the search for a cholesterol-lowering drug. Research had already shown cholesterol is mostly manufactured by the body in the liver, using the enzyme HMG-CoA reductase. Endo and his team reasoned that certain microorganisms may produce inhibitors of the enzyme to defend themselves against other organisms, as mevalonate is a precursor of many substances required by organisms for the maintenance of their cell walls (ergosterol) or cytoskeleton (isoprenoids). The first agent they identified was mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum.
A British group isolated the same compound from Penicillium brevicompactum, named it compactin, and published their report in 1976. The British group mentions antifungal properties, with no mention of HMG-CoA reductase inhibition.
Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs. P. Roy Vagelos, chief scientist and later CEO of Merck & Co, was interested, and made several trips to Japan starting in 1975. By 1978, Merck had isolated lovastatin (mevinolin, MK803) from the fungus Aspergillus terreus, first marketed in 1987 as Mevacor.
A link between cholesterol and cardiovascular disease, known as the lipid hypothesis, had already been suggested. Cholesterol is the main constituent of atheroma, the fatty lumps in the wall of arteries that occur in atherosclerosis and, when ruptured, cause the vast majority of heart attacks. Treatment consisted mainly of dietary measures, such as a low-fat diet, and poorly tolerated medicines, such as clofibrate, cholestyramine, and nicotinic acid. Cholesterol researcher Daniel Steinberg writes that while the Coronary Primary Prevention Trial of 1984 demonstrated cholesterol lowering could significantly reduce the risk of heart attacks and angina, physicians, including cardiologists, remained largely unconvinced.
Society and culture
To market statins effectively, Merck had to convince the public of the dangers of high cholesterol, and doctors that statins were safe and would extend lives. As a result of public campaigns, people in the United States became familiar with their cholesterol numbers and the difference between "good" and "bad" cholesterol, and rival pharmaceutical companies began producing their own statins, such as pravastatin (Pravachol), manufactured by Sankyo and Bristol-Myers Squibb. In April 1994, the results of a Merck-sponsored study, the Scandinavian Simvastatin Survival Study, were announced. Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%. In 1995, Zocor and Mevacor both made Merck over US$1 billion. Endo was awarded the 2006 Japan Prize, and the Lasker-DeBakey Clinical Medical Research Award in 2008. For his "pioneering research into a new class of molecules" for "lowering cholesterol," Endo was inducted into the National Inventors Hall of Fame in Alexandria, Virginia in 2012. Michael C. Brown and Joseph Goldstein, who won the Nobel Prize for related work on cholesterol, said of Endo: "The millions of people whose lives will be extended through statin therapy owe it all to Akira Endo."
Research continues into other areas where specific statins also appear to have a favorable effect, including dementia, lung cancer, nuclear cataracts, hypertension, and prostate cancer.
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The secret behind Donald Trump's hair 01:59, CNN (February 3, 2017)
The President's use of this medication was not disclosed by his doctor during campaign
Propecia is a low dose formulation of finasteride used to promote hair growth
President Trump is taking a prostate drug often prescribed for hair loss, his physician Dr. Harold N. Bornstein told the New York Times in an interview published Wednesday. He also made a point of stating that the President has all of his hair.
The New York City gastroenterologist also said the President is taking antibiotics to control rosacea, a skin condition that causes redness.
A senior White House official says Bornstein did not have Trump's permission to speak about his health to the Times.
The physician told the Times he has had no contact with his patient since Trump became president. Trump had visited his office every year since 1980 for annual checkups, colonoscopies and other routine tests.
During the campaign, Trump's longtime physician disclosed only that he was taking rosuvastatin and low-dose aspirin to reduce his risk of heart attack.
Bornstein came under scrutiny for a letter he wrote describing Trump's physical health that concluded, "If elected, Mr. Trump, I can state unequivocally, will be the healthiest individual ever elected to the presidency."
Other doctors found the letter's conclusion unprofessional and said Bornstein had used strange wording and medically incorrect terms when referring to his high-profile patient. Bornstein told CNN in September that he was rushed for time and had patients to see when writing the letter.
What is Propecia?
Propecia is a lower-dose formulation of finasteride that is prescribed to men with enlarged prostate glands under the brand name Proscar.
Originally, the Food and Drug Administration approved finasteride 5 mg (Proscar) in 1992 for the treatment of "bothersome symptoms in men" with an enlarged prostate, which is also referred to as benign prostatic hyperplasia. At that time, the FDA also approved Proscar to reduce the need for surgery related to an enlarged prostate and possible urine retention.
In 1997, the agency approved a lower-dose formulation of finasteride (Propecia) for the treatment of male pattern hair loss, a gradual thinning that leads to either a receding hairline or balding on the top of the head. The FDA does not permit Propecia for treating hair loss in women or children.
"It is a very common medication," said Dr. Louis Kavoussi, chairman of urology at Northwell Health in New Hyde Park, NY. He added that finasteride has been around for decades, so its long-term safety has been demonstrated.
The drug, which blocks the body's production of male hormones, is in a class of medications called 5-alpha reductase inhibitors.
"The effectiveness varies," said Kavoussi, who has no ties to Merck or the companies that make generic versions of finasteride. Though some men who take it for hair loss find it "very effective," others do not. "Same for prostate," he said. "Some men gain quite a bit of symptom relief, other men more modest. It depends on the patient."
Possible side effects of the finasteride include decreased libido, problems with erection and ejaculation, pain in the testicles and depression. According to drugmaker Merck's prescribing information, patients taking the drug should promptly notify their doctor if they experience changes in their breasts, rash, itching, hives, swelling of the face or hands, or difficulty breathing or swallowing.
According to Kavoussi, "most men tolerate it pretty well." Those who do get side effects simply stop taking the medicine, and the effects resolve.
For some years, Merck has been a defendant in liability lawsuits regarding Propecia/Proscar.
About 1,370 lawsuits have been filed as of September 30 by people who claim that they have experienced persistent sexual side effects after cessation of treatment with Propecia and/or Proscar. About 50 of the plaintiffs also allege that the drug has caused or can cause prostate cancer, testicular cancer or male breast cancer.
Dr. Irwin Goldstein, founder of San Diego Sexual Medicine, is serving as an expert witness against Merck in the ligation, work for which he is being paid. He said people come to his clinic "from all over the world" for help with finasteride-associated symptoms.
Many patients experience "a sudden or significant change in libido," he said, while another common side effect is erectile dysfunction. Along with these sexual effects, Goldstein said the drug can cause problems with both mood and cognition, including harmful effects on memory and decision-making.
Some patients believe they suffer from "post-finasteride syndrome," in which their symptoms continue after they stop taking the drug.
As of March 2015, the syndrome is listed on the National Institutes of Health's Genetic and Rare Diseases Information Center, with the disclaimer that this is not intended as "official recognition" of the syndrome. Still, the National Institutes of Health has sponsored studies, which are now underway, to better understand the effects of finasteride.
"You don't want people to shy away -- and that's the bad thing about lawsuits; people get the impression that something is very bad," Kavoussi said, adding, "it's helped a lot of men."
Merck listed 2015 sales of the drug at $183 million, down from a peak of $447 million in 2010. Other drug manufacturers began producing generic versions in 2013.
Efforts to contact Bornstein for comment have not been successful.
ROSACEA: DIAGNOSIS AND TREATMENT
How do dermatologists diagnose rosacea?To diagnose rosacea, a dermatologist examines the skin and eyes. Your dermatologist also will ask questions.
How do dermatologists treat rosacea?
Dermatologists can remove the thickening skin that appears on the nose and other parts of the face with: